1. Add your ASIO driver. Right-click the canvas → ASIO Channels → Add ASIO driver…, pick your interface and click Open Device. (No ASIO interface? Use your microphone and speakers from the WDM/MME folder instead and skip this step.)
  2. Add the input. Right-click → ASIO Channels → Input → the channel your microphone is on.
  3. Add the outputs. Right-click → ASIO Channels → Output → your speakers' left channel, then again for the right. Each ASIO channel is its own mono node.
  4. Connect. Drag from the input's port to each output's port, or click one port and then the other. Esc cancels.
In 1
ASIO/Focusrite USB ASIO
Output
Mono
Out 1
ASIO/Focusrite USB ASIO
Input
Mono
Out 2
ASIO/Focusrite USB ASIO
Input
Mono

To change a connection's level, click the wire: its inspector sets gain from -60 dB to +36 dB. Alt + click resets it to 0 dB.

Save with ⋮ → Save. On Free the canvas starts empty at every launch; see Sessions and State.

Nothing heard? Watch the meters: a still input meter means the wrong channel; a still output meter means the wire is missing. Crackling means the buffer is too small - raise it in the toolbar.